Volume - 13 | Issue-1
Volume - 13 | Issue-1
Volume - 13 | Issue-1
Volume - 13 | Issue-1
Volume - 13 | Issue-1
Ultraviolet B (UVB) radiation is one of extrinsic factors that accelerates the premature aging process of the skin, which is called photoaging. Photoaging is characterized by the appearance of wrinkles due to excessive exposure to UVB rays. Clitoria ternatea flowers are one of herbal plant that have been reported for their chemical content of flavonoids. Based on the literature, flavonoids are one of the natural compounds that have potential effect as a photoprotective agents because they have the ability to absorb UVB light and can be antioxidant compounds. This research aim is to evaluate cream containing Clitoria ternatea flower extract 2.5% and 5% to increase skin fibroblas on the skin of wistar rats exposed to UVB. The indicator use number of fibroblasts in the epidermis with Hematoxylin Eosin staining. Twenty-five male white rats (Rattus norvegicus) randomly separated into five groups comprising normal control (0.9% NaCl), negatif control (UVB exposure), positif control (UVB exposure + suncreen cream), and two treatment groups (UVB exposure treated with Clitoria ternatea cream flower extract 2.5% and 5%). The findings indicated that the negative control group had the lowest average number of fibroblasts compared to the other groups. The treatment group which received Clitoria ternatea cream flower extract cream 2.5% had higher average number of fibroblasts than control negatif group. Furthermore, the treatment group which receive Clitoria ternatea cream flower extract 5% had same average number of fibroblasts as the normal control group. This study can provide information by proving that Clitoria ternatea cream flower extract 2.5% and 5% can increase the number of skin fibroblasts exposed to UVB light.