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ISSN 2063-5346
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Co (II), Ni (II) and Cu (II) metal compounds of 2-aminonicotinaldehyde: Synthesis, crystalline structure, pharmacological assessment, and molecular docking research are all part of the process

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N. KOTILINGAIAH, A. NAGARJUNA, B.M PRAVEEN , B SRINU, K. SATEESH
» doi: 10.48047/ecb/2023.12.si4.607

Abstract

The ligand 2-aminonicotinaldehyde (2-ANA) and metal compounds of [Cu(2-ANA)2Cl2], [Ni(2-ANA)2Cl2], and, [Co(2-ANA)2Cl2] have synthesis and research by using analytic and spectroscopical techniques (UV, IR,1H-NMR and Mass). The 2-ANA and [Co(2-ANA)2Cl2] complex single crystal X-ray diffraction experiments have been describe. Both compounds have intra/intermolecular hydrogen bonding, and the N-particle of the pyridine ring of 2-ANA is tetrahedrally coordinate to M-ion. Molecular docking research for microbiological examination, antioxidants, in antibacterial activity, and EGFR target were performed on metal chlorides, 2-ANA, and their complexes, which revealed that metal complexes have a synergistic effect on biological activity when compared to liberal ligand and M-Cl

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