The solubility of a medicine is influenced by the excipients employed in its preparation. The incorporation of binders in tablet formulation plays a pivotal role in enhancing the solubility of both the dose form and the active pharmaceutical ingredient. This study aimed to explore the utilisation of natural excipients in order to enhance the solubility and dissolving rate of a pharmaceutical compound. A novel and stable cocrystal of famotidine (FMT) was successfully synthesised using crystal engineering techniques. The coformer (CCF) selected for this cocrystallization process was m-nitrobenzoic acid (MNBA), which is a pharmaceutical intermediate containing a carboxylic acid group