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ISSN 2063-5346
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COGNITIVE AND NEUROCHEMICAL EFFECTS OF AEGLE MARMELOS L. STEM BARK EXTRACTS IN WISTAR RATS: IMPLICATIONS FOR ANTIDEPRESSANT POTENTIAL

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Shriniwas K. Sarje, Vijay N. Gunjkar, Mangal L. Pawde, Anup T. Sharma, Sagar. N. Firke
» doi: 10.48047/ecb/2022.11.12.022

Abstract

The contemporary era is characterized by its swift pace, and while allopathic medicines undoubtedly offer rapid outcomes, their efficacy is accompanied by a range of adverse effects and contraindications. Conversely, botanical resources present a promising alternative, marked by minimal to negligible side effects and a propensity to address underlying issues. Among these botanical resources, Aegle marmelos, a member of the Rutaceae family, holds particular prominence within the realm of medicinal applications. This study centers on the meticulous exploration of phytochemical attributes and the rigorous evaluation of pharmacological dynamics associated with Aegle marmelos, colloquially recognized as "bael" in India. The stem bark of Aegle marmelos was meticulously sourced from the local environs of Nanded, Maharashtra. Methodologically, phytochemical constituents were extracted via a Soxhlet extraction approach, utilizing ethyl acetate and methanol solvents. Focusing on the antidepressant potential, the efficacy of Aegle marmelos L. stem bark was gauged through the application of the despair swim test and tail suspension test. The standard comparator in this context was imipramine (10mg/kg). Notably, both extracts at a concentration of 200mg/kg exhibited marked to highly significant outcomes, signifying a noteworthy reduction in immobility time (ranging from P<0.005 to P<0.001). In essence, this investigation underscores the multifaceted attributes of Aegle marmelos, unraveling its potential as a therapeutic entity. The pursuit of this botanical resource extends to the systematic delineation of ethyl acetate and methanolic extracts, complemented by meticulous phytochemical screening and a nuanced evaluation of antioxidant and antidepressant potential. The underpinning methodologies, namely the despair swim test and tail suspension test, collectively contribute to a comprehensive understanding of Aegle marmelos' therapeutic capacities.

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