Post-operative pain management is a critical aspect of patient care that directly impacts recovery outcomes and overall satisfaction. Nurses play a pivotal role in addressing post-operative pain through various interventions aimed at alleviating discomfort, promoting healing, and enhancing patient well-being. This review article explores the current landscape of post-operative pain management strategies employed by nurses and highlights the effectiveness of different nursing interventions in improving patient outcomes. The review discusses the importance of individualized pain assessment, multimodal analgesia approaches, patient education, non-pharmacological interventions, and the role of technology in enhancing pain management practices. Furthermore, the review examines the challenges and barriers faced by nurses in effectively managing post-operative pain and provides insights into potential solutions and best practices.