Introduction- Dry eye disease is a multi-factorial disease of the tear and ocular surface that result in symptoms of discomfort. It is a common condition that occurs when your tear aren’t able to provide adequate lubrication for your eye. Purpose Dry eye disease (DED) is a common age-related ocular surface disease. However, it is unknown how aging influences the ocular surface microenvironment. This systematic review aims to investigate how the aging process changes the ocular surface microenvironment and impacts the development of DED.