In recent years, there has been a growing interest in natural medicine, with a shift towards utilizing herbal remedies for various health conditions. This study protocol was designed to investigate the hepatoprotective and anti-inflammatory potential formulations derived from selected indigenous medicinal plants, Cayratia trifolia, Sesbania grandiflora, Cordia dichotoma, and Tephrosia purpurea, collected from Kandhamal district, Odisha.