Objectives: The aim of the present work was to prepare and evaluate dispersible tablets of Nimesulide with a view to enhancing patient compliance and minimizing the side effects. Methodology: In this study, dispersible tablets of nimesulide were formulated by direct compression method using such as pectin of mango peel (Mangifera indica), Hibiscus rosa sinensis was used as natural disintegrants and crospovidone as a synthetic super disintegrant in different ratios. The prepared formulations were evaluated for hardness, friability, drug content, in vitro dispersion time, wetting time, water absorption ratio, in vitro drug release studies.