Neuropathic pain is caused by a primary lesion or dysfunction in the nervous system. It may result from the damage to the central nervous systems (cerebrovascular accident, multiple sclerosis or injury to the spinal cord) or peripheral nervous system (peripheral neuropathy associated with diabetes, post herpetic neuralgia or surgical interventions). Diabetic Peripheral Neuropathic Pain (DPNP) is characterized by a burning, electrical shock type, lancinations and deep aching pains in the lower extremities. It has sudden onset usually affecting the sleep pattern, reducing productivity and quality of life along with mood disturbances. The commonly used medications for the treatment of Diabetic Peripheral Neuropathic Pain are antidepressants, antiepileptics, opioids, analgesics, topical lidocaine and topical capsaicin for symptomatic analgesic therapy. The pharmacological response among individuals with this condition is varied and most treatments are not very effective in more than half of the patients. Treatment options vary from monotherapy to various combination therapies. Many trails were conducted in patients with peripheral diabetic neuropathic pain that proved the efficacy and safety of different treatment options.