Background: Oral mucositis is dreadful side effect of cancer therapy. It occurs in almost all patients who receive radiotherapy/chemotherapy for head and neck cancer. Objectives: To compare efficacy of benzydamine mouthwash with other mouthwash in radiation induced oral mucositis, in terms of reduction in severity and pain. Methods: Computerized literature searches were performed to identify all published articles in the subject from 1988-2022. Following databases were used: PubMed (MEDLINE), Cochrane, and Google Scholar. Randomized controlled trials were included, that compared benzydamine mouthwash with either placebo or any other mouthwash in patients with radiation induced oral mucositis. Data was extracted in a predefined fashion.