Introduction:Worldwide, dental caries is recognized as the most common microbial disease of complex etiology.The most important bacteria responsible for caries initiation isStreptococcus mutans. Studies in the field of caries prevention have shown that it is difficult to completely eliminate Streptococcus mutans from oral cavity by mechanical and chemical control only. Consequently, alternative ways to affect the oral ecology have emerged such as administration of probiotics which alters the bacterial ecology and antagonizes their growth. Aim:The aim of the study was to evaluate the inhibitory effect of dentrifice (Purexa) and mouthwash (Perfora) formulated with probiotics on salivary Streptococcus mutans in caries-risk population. Materials And Methods: 18-30 years old subjects were selected who underwent a second round of screening to determine the pH of saliva. 60 subjects with salivary pH <5.5 were included in the study which were then divided into 3 groups (n=20):  Group A (n=20): Fluoride dentrifice without mouthwash (Control group)  Group B (n=20): Probiotic dentrifice (Purexa) without mouthwash  Group C (n=20): Fluoride dentrifice with probiotic mouthwash (Perfora) All subjects were provided with necessary instructions regarding the use of the dentrifice and mouthwash. Two ml of unstimulated saliva was collected on the 1st day as baseline data and after 14 days of intervention and Colony forming Unit (CFU) of S. mutants on Mitis Salivarious Agar was calculated.Data was analyzed using Wilcoxon Signed Rank Test and Mann Whitney U Test. Results: There was a significant reduction in S. mutanscount in both the experimental groups as well as the control group after an intervention period of 14 days. However, probiotic dentrifice (Group B)and probiotic mouthwash (Group C) resulted in significantly more reduction in salivary S. mutans count when compared to subjects using only fluoridated dentrifice (Group A) with the highest reduction observed in Group C. Conclusion: Administration of probiotics inhibited the growth of S. mutans and resulted in significant reduction of this caries-causing micro-organism. Early integration of probiotics in oral health regimens may go a long way in preventing the development and further progression of carious lesions and thereby serve as an invaluable caries-preventive measure.