The current study aims to assess clinically the occurrence of postoperative discomfort following endodontic treatment utilising the Protaper Next and WaveOne Gold file systems. Material and Method: The study involved 30 healthy teeth with irreversible pulpitis but no periapical lesions. Protaper Next and Waveone gold were the two instrumentation systems used, and the patients were split into two groups (n=15). One session was used for all of the treatments. After 12 hours, 24 hours, 72 hours the participants were asked to rate their level of postoperative pain on a visual analogue scale (VAS) (no pain, mild discomfort, moderate pain, and severe pain). All the results are calculated by using Statistical Package for the Social Sciences (SPSS) version 22 and statistically analyzed. Result: After 12, 24 and 72 hours, the incidence of postoperative pain is much lower in the Protaper next group than it is in the Waveone gold group. Conclusion: In comparison to the Protaper Next file, increased postoperative pain is anticipated following the preparation of the root canal system using WaveOne Gold.