Oral administration is the most beneficial choice for drug delivery since it ensures improved patient compliance. However, the primary obstacles to efficient oral drug delivery are medicines' low metabolic/enzymatic stability and their difficulties dissolving in water. Among other methods, nanotechnology-based drug delivery systems can solve problems with oral medicine administration. Nanotechnology-based drug delivery systems allow the administration of antihypertensive drugs with improved therapeutic impact and bioavailability. In order to combine data on the improvement of oral bioavailability area under curve (AUC) by nanotechnology from several investigations, meta-analysis was used in this study. 21 studies from different countries were considered. Bioavailability was 95% CI [1.05–3.02], based on the total improvement potential of nano-formulations based on a drug delivery system. This study divided the vast and current data used to illustrate how nanotechnology improves bioavailability into five categories - solid lipid nanoparticles and nanoparticles made of polymers. Additionally, the findings of the meta-analysis showed that many treatments had a high relative bioavailability.