The free radicals called reactive oxygen or nitrogen species associated to the development of illnesses like cancer, stroke, and diabetes. Antioxidant from plants is a viable strategy for reducing the negative consequences of oxidative stress. Thus, this study deals with comparative phytochemical analysis & antioxidant potential of Tinospora cordifolia & Momordica charantia. The leaves of plant were collected & studied for organoleptic properties & then subjected to extraction by ethanol as solvent. Further Qualitative as well as quantitative studies were performed. The antioxidant potential of both plants was checked by DPPH & H2O2 assay. Results revealed that The Loss on Drying for Tinospora cordifolia & Momordica charantia noticed as 5.96% & 4.73% respectively. The Phytochemical analysis of Tinospora cordifolia revealed to have presence of alkaloid, glycoside, carbohydrate, tannin, flavonoid, steroid, protein & saponin. The Momordica charantia phytochemical test remarked almost similar results. In case of Momordica charantia the total phenol & flavonoid content was recorded as 4.33±0.055mg/100mg & 20.63±0.046 mg/100mg respectively. For the plant Tinospora cordifolia the phenol & flavonoid content estimated to have 14.33±0.055mg/100mg & 20.63±0.046 mg/100 mg respectively. The Momordica charantia seem to have IC 50 value of 80.32±0.100. While Tinospora cordifolia assessed to have IC 50 value of 80.25±0.055. So, it can be observed that both plants have almost similar antioxidant potential. The hydrogen peroxide radical scavenging assay IC 50 value for Tinospora cordifolia & Momordica charantia observed to have IC 50 as 3.48±0.050 & 3.51±0.206 respectively. Thus, from results it can stated as slightly higher antioxidant capability is present in Momordica charantia.