Thalassemia (thal) is one of the most frequently genetically transferred diseases and is related to the decreased production of structurally normal hemoglobin. Objectives: This study aimed to compare the physical growth constraints in thalassemia kid and healthy school-going children between the age group of 5-15 years. Methodology: The study was conducted in a multicenter cross-sectional study. A total of 50 thalassemic children were recruited in the study and 50 healthy children as a control group. Thalassemic children and controls were matched for age, sex, height and weight. Result: The mean weight of the thalassemic children (23.74 kg) was significantly less as compared to control children (30.66 kg) (P=0.00198). The mean body mass index (BMI) of the children was significantly lower than that of the control group children (15.21 kg/m2 vs 16.65 kg/M2) (p=0.00139). Conclusion: The study suggested that growth parameters such as height, weight, and BMI were significantly less and most commonly affected in Thalassemia children compared with their healthy counterparts. The results suggested that in 5-10 years age group weight is more affected than height where as in 10-15 years both weight and height are equally affected