6-methyl-benzofuran-3-acetic acid has been utilized to synthesize 5- benzofuranylmethyl-2-aminothiadiazole with thiosemicarbazide. This illustrates the 4+1 approach for the construction of the five members heterocyclic. The core nucleus benzofuranyl imidazo[2,1-b] [1,3,4] thiadiazoles has been synthesized by the reaction of 3with appropriately substituted phenacyl bromides. This second approach is characteristic of the 3+2 that is double nucleophile and double electrophile approach. These crystal structured compounds may exhibit various biological and pharmacological action with various level of concentration. In future study will be concluded with in vitro and in vivo studies to investigate the potential biological property to make it commercial and to become economical compound in the industry.