Knee joint pain is a prevalent and debilitating condition among the elderly population, significantly impacting their quality of life and daily activities. Understanding the differences in knee joint pain between elderly men and women is crucial for effective management and tailored interventions. This comparative study aims to investigate and compare the prevalence, severity, and associated factors of knee joint pain among elderly men and women from rural areas in Chennai. The study will employ a cross-sectional design, recruiting a representative sample of elderly individuals aged around 50 years and above from various community settings. The participants will undergo a structured interview and clinical examination to assess knee joint pain, including its onset, duration, intensity, and functional limitations. Furthermore, demographic, anthropometric, lifestyle, and medical history data will be collected to identify potential risk factors associated with knee joint pain. Statistical analyses, including chi-square tests, t-tests, and logistic regression models, will be employed to determine the differences in knee joint pain prevalence and severity between elderly men and women. Additionally, the study will explore the associations between knee joint pain and various factors, such as age, body mass index, physical activity level, comorbidities, and hormonal status. The findings of this study are expected to provide valuable insights into the gender-specific patterns of knee joint pain among the elderly population. It is hypothesized that women may experience a higher prevalence and severity of knee joint pain compared to men due to hormonal factors, differences in biomechanics, and age-related musculoskeletal changes from rural areas of Chennai. Understanding these gender differences will enable healthcare professionals to develop targeted interventions and personalized treatment strategies to alleviate knee joint pain in elderly individuals. Ultimately, this study aims to contribute to the existing literature on knee joint pain, promote evidence-based clinical practice, and enhance the overall well-being of elderly men and women by addressing their specific needs in managing knee joint pain