To evaluate the analgesic and anti-inflammatory activities of the alcoholic extract of aerial parts of Spilanthes acmella(murr.) and Bryophyllum Pinnata (Lam.) in experimental animal models. Material and methods– Spilanthes acmella(Murr) and Bryophyllum pinnata (Lam.) were evaluated for anti inflammatory action by carrageenan- induced rat paw edema. The analgesic activity was tested by tail flick method in albino rats. Result-The alcoholic extract of Spilanthes acmella and bryophyllum pinnata (Lam.) at a doses 500 mg/kg showed 52% and 60% inhibition of paw edema respectively at the end of three hours and the In the tail flick model, the alcoholic extract of Spilanthes acmella and bryophyllum pinnata (Lam.) in the above doses increased the pain threshold significantly after 30 min, 1,2 and 4h of administration. SPA showed dose-dependent action in all the experimental models Conclusion-The present study indicate that the alcoholic extract showed significant analgesic activity and anti-inflammatory activity at dose 500mg/kg BW.