Background: Proper sternal closure greatly reduces the incidence of sternal dehiscence and sternal wound infection. The purpose of our study is to address the effects of the different techniques of sternal closure in order to determine the standard technique. Methods: The study was conducted on 150 patients and divided into three groups, A, B, and C, each including 50 cases. Regarding group A, the closure of the sternum was with a simple interrupted technique; in group B, the closure was with the figure of eight technique; and in group C, the closure was with a multi-twisted (Prakash) wire technique. Patients of the study underwent cardiac surgeries at cardiothoracic surgery departments at Cairo University and Beni Suef University hospitals during the period between September 2022 and April 2023. Results: The incidence of sternal dehiscence in our study was 4%, 6%, and 8% in groups A, B, and C, respectively, with no significant differences between the three groups. There were no significant differences between the three groups regarding early postoperative complications like postoperative bleeding, wound infection, postoperative pain, and return to normal activity. Conclusion: Different techniques of sternal closure as simple interrupted, figure-of-eight, and Prakash (multi-twisted wire) techniques, might have similar results regarding the development of sternal dehiscence as well as early postoperative complications like postoperative bleeding and infections.