Introduction: Cataract is an eye disorder in the form of cloudiness of the lens caused by hydration of the lens fluid. In Indonesia, the leading cause of blindness is cataract, especially in North Sumatra. Cataract surgery with phacoemulsification technique can cause inflammation. As respond to inflammation, 0.1% dexamethasone eyedrops and 0.1% diclofenac sodium eyedrops was given. This study was conducted to determine the effectiveness of suppressing inflammation between 0.1% dexamethasone and 0.1% diclofenac sodium eyedrops after phacoemulsification cataract surgery. Methods: This study is an experimental study with a double-blind design at General Hospital of Sumatera Utara and Medan Baru Eye Centre with senile cataract patients as the sample. Patients with inflammation response such as cell and flare on the first day after phacoemulsification cataract surgery was included as the samples if the patients fulfilled inclusion criteria and not included in exclusion criteria. Cell and flare examination was done in day one, three, seven and fourteen after the given eyedrops. Data collected was then analyzed using T-paired test with significance level of p<0.005. Results: This study found significant difference between dexamethasone eyedrops and diclofenac sodium eyedrops in day one (p=0.004), in day three (p=0.035), and in day seven (p=0.005). In day fourteen, no significant difference was found between dexamethasone eyedrops and diclofenac sodium eyedrops (p=0.119). Conclusion: Diclofenac sodium eye drops have a better anti-inflammatory effect compared to dexamethasone eyedrops in reducing the inflammatory reaction of cell and flare in the camera oculi anterior with patients after phacoemulsification cataract surgery in General Hospital of Sumatera Utara and Medan Baru Eye Centre.