Objective: The goal of this study is to analyze the influence of growth hormone (GH) replacement (daily versus long acting) on patient-reported outcomes (i.e., quality of life, health status and well-being) and cognitive functioning in GH-deficient adults by systematic review of the published clinical trials. Design: A meta-analysis of clinical trials concerning the influence of GH substitution on patient-reported outcomes and cognitive functions (studies will be selected from 2000 to 2022). The results of individual studies will be combined in a series of meta-analyses using a random effects model. Effects of GH replacement (daily versus long acting) in GH-deficient adults will be compared. Expected outcome: This meta-analysis may provide an evidence of a better GH analogue (daily Vs long acting) in improving patient-reported outcomes in GH-deficient patients. As the amount of cognitive data is too limited to allow for comparisons with the two analogues of GH, conclusions may be drawn with respect to the impact of GH daiy vs long acting) treatment on cognition.