Background : Burns caused by radiation, heat, chemicals, electricity or friction can cause damage to tissues including the skin. Aloe vera (Liliaceae family) is one of the most recognized herbs in the world. Glucomannan and acemannan in aloe vera are the active chemical compounds which can stimulate proliferation and fibroblast activity. Meanwhile, Silver sulfadiazine (SSD) is the gold standard in burn therapy because it is a broad spectrum antibiotic and is not resistant. However, in several studies on SSD it was found that SSD can inhibit wound healing in vivo, cytotoxic effect on keratinocytes and fibroblast in vitro. After burn injury, ROS is being produce in a large amount and can be dangerous. ROS also has implication for tissue damage, infection and sepsis, inflammation, systemic response syndrome, multiple organ failure and immunosuppression. Free radicals change the components of cell membranes and produce toxic compounds such as MDA (Malondialdehyde) which are formed as a result of lipid peroxidation. Superoxide Dismutase enzyme is an enzyme that plays a role in the first process to counteract free radicals. An increase in the inflammatory response also occurs in burns causing an increase in CReactive Protein. This aim of this study is to determine the effectiveness of Aloe Vera extract and SSD on MDA and SOD levels with CRP as a biomarker in rats with Mid-Dermal burns.