Background: Degeneration of the lumbar intervertebral disc is a major factor associated with low back pain. The term prolapsed disc means the protrusion or extrusion of the nucleus. It is not a onetime phenomenon rather it is a sequence of change in the disc which ultimately leads to its prolapsed. It is a spinal condition that can cause lower back pain as well as numbness, tightness of muscle, pins and needles sensation, and feeling of muscle weakness in the lower body. Objective: The study aims to assess the effect of core strengthening exercise and McKenzie exercise in patients with PIVD (lumbar spine) through ROM of flexion and extension. Methods: This experimental comparative study was carried out after the approval of Pacific Medical University, Institute‟s ethical approval obtained dated 06/09/2022, PMU/ PMCH/IEC/2022/228. All participants completed information and consent form at recruitment. 30 subjects were chosen based on inclusion and exclusion criteria and randomly assigned to 2 groups of 15 subjects each. Exercises for McKenzie extensions were given to Subjects in Group A, while Core-strengthening exercises were given to Subjects in Group B. Both groups received treatment for six weeks. Both groups received treatment five times per week for a period of six weeks. On the first day of every week until the conclusion of the six weeks, patients were assessed through ROM of flexion and extension. Results: In terms of pain alleviation, muscle strength, and functional performance, this study found that individuals with prolapsed intervertebral discs (a disorder affecting the lumbar spine) responded better to core strengthening exercises than McKenzie extensions. Conclusion: The statistical analysis of the current study shown that the core strengthening exercise programme was very effective in treating low back pain brought on by prolapsed intervertebral discs (Lumbar spine disease). As a therapeutic approach, it is successful in lowering pain and functional impairment.