This original research article focuses on the burgeoning significance of nanocomposites in biomedical and pharmaceutical domains due to their heightened properties. The research aims to assess the compatibility of Guar Gum (GG)/Methyl Cellulose (MC) blend-Zinc Oxide (ZnO) nanocomposites using a range of analytical techniques. ZnO nanoparticles were synthesized utilizing banana leaf extract and zinc acetate solution. To validate compatibility within the aqueous solutions, the study employed density measurement, ultrasonic velocity measurement, and adiabatic compressibility measurements. The characterization of the morphology of thin films prepared via the solution casting-solvent evaporation method was accomplished through FESEM analysis. The outcomes unveiled the compatibility and stability of GG/MC blend-ZnO nanocomposites in aqueous solutions, presenting these materials as promising candidates for diverse biomedical and pharmaceutical applications. This study significantly contributes by examining the compatibility of GG/MC blend-ZnO nanocomposites through an array of analytical methods.