The complexity of the healing process and the diverse character of the wound environment make wound healing studies challenging. Various cells and repair phases participate in healing process include Haemostasis, proliferation & re-epithelialization, Inflammation or remodelling. To test the new therapeutic drugs there is a need to conduct pre-clinical studies on animal models, such as mice, rats, pigs & rabbits. A variety of techniques has been used to induce or create the wound. This article provides an overview of wound models to evaluate wound healing activity. The aim of this article is to help researchers design &execution the wound healing experiment.