The exclusive aim of this study was to assess plugged out bond strength of commercially available mineral trioxide aggregate and biodentine. Materials & Methods: Two commercially available bioactive dental materials Septodont Biodentine and MTA were studied in two groups. Sampling was done carefully for 24 maxillary lateral incisors with strict predetermined inclusion criteria. Samples were cleaned and sectioned to remove apical and coronal one third segment of tooth. Further transverse re-sectioning of the piece leaving middle 2 mm potions were also done. Group one has total 12 maxillary lateral incisors samples in which Septodont Biodentine was used. Group two has total 12 maxillary lateral incisors samples in which MTA was used. All samples were then tested for their plugged out bond strength by universal testing machine. The maximum load required to dislodge the cement plug was recorded in Newton. P value less than 0.05 was considered significant (p< 0.05). Statistical Analysis and Results: The statistical analysis was conducted by SPSS software. All preliminary data was entered into excel sheet and entered into computer. For Group I, the mean plugged out bond strengths for group I was 4.62. The calculated standard deviation was 0.948 and measured standard error was 0.647. The p value was highly significant (0.02). For Group II, the mean plugged out bond strengths for group II was 1.31. The calculated standard deviation was 0. 637 and measured standard error was 0.466. The ANOVA testing confirmed about highly significant p value (0.001). Conclusion: Within the limitations of the study authors concluded that Biodentine has high plugged out bond strength compared to the MTA. Biodentine showed highly significant values also. However, authors anticipate some other studies to be conducted with larger samples size and thorough analysis.