When it comes to clinical services, safety in the medication process is one of the vital aspects of health service delivery. The scrutiny that this review makes is a holistic one; it involves best practices in medication dispensing and administration to maintain patients' safety. The study is holistic and focused on best practices for medication dispensing and administration and patient safety. This paper focuses on significant aspects of medication processes by analyzing literature, syllabuses, theories, and practices. It will scrutinize the obstacles in medication processes and explore potential solutions. Such findings set forth the issue of having a stricter policy for the use of medication, closer supervision of clinical personnel, and the application of advanced technologies to prevent medical errors and improve patients’ health care.