Vaccination in children's health programs, which helps in the control of the spread of infectious diseases and the promotion of the health of communities, is of the utmost importance. This overarching review performs a close examination of how well those programs work and their risks separately from delving into the complex personality features behind vaccine rejection among pediatric populations. Using a rigorous systematic literature review approach, this article provides a thorough literature review and specifies the gaps in knowledge about the vaccination issue for children on a global scale. Combining the outcomes of various research works into one provides us with a deep understanding of areas waiting for more in-depth research. To add to this, such a review comes with tactics that are tailored to growing vaccination uptake rates and vaccine hesitancy among the population. By conducting a well-informed assessment and proposing evidence-based solutions, this paper supports the international discussion on unnecessary childhood immunization. The main aim is to enhance public health initiatives and ensure the safety of children globally.