The component of radiotherapy that has emerged as an indispensable component in contemporary cancer care protocols is brachytherapy. The main goal is to explain the critical points of the intricate structure of establishing brachytherapy within modern oncological processes. The precision and safety of brachytherapy will be looked into. The article will also highlight the technical advancements that have brought brachytherapy to the forefront. This study seeks to explain the wide-ranging landscape of brachytherapy in combination therapy through research. Through such a review, it will focus on the most significant improvements in the field along the lines of techniques and precision, among others, for different types of cancer. Furthermore, it investigates the possibility of leveraging the best of breast brachytherapy when integrated with other means such as chemotherapy, immunotherapy, and surgery, presenting the full benefit of dosage variety to the reader. Among others are the selection criteria for patients, the strategies' planning that depends on the characteristics of patients, the dose escalation, and the overall outcome assessment. Additionally, the review highlights the fact that ongoing studies and innovative technology development are essential in improving brachytherapy procedures globally. Finally, the goal of this research includes creating a proper database, which will provide clinicians, researchers, and policymakers with meaningful information on how to further enhance the utility of brachytherapy in the era of precision oncology.