Transferosomes are one of the novel vesicular systems for transdermal delivery of active substance. They are capable of transdermal delivery of drug with low and high molecular weight with uniqueness of accommodating hydrophilic, lipophilic and ampiphilic nature of molecules. These are second generation of flexible liposomes consisting of phospholipid and edge activator. Advantages of transferosomes are high entrapment efficacy, high deform ability, use for both systemic as well as topical, biocompatible, biodegradable, protects drug from degradation and easy to sale up as procedure of preparation is simple