Parkinson’s is one of the major neurodegenerative disease of Alzheimer’s, affects more than 6 million people around the word by causing motor dysfunction. In recent years natural products are widely used in the field of medicine. Garcinia morella is one of the major traditional plant which has antioxidant, antifungal, antiviral, hepatoprotective, anticancer, anti-inflammatory, antibacterial, and larvicidal active properties. Flavonoids are majorly reported for its capacity of crossing Blood Brain Barrier and slow down the progression of neurodegeneration. In the current study, we have screened for the flavonoids present in the Gracinia morella plant to analyse the activity of flavonoids against alpha synuclein using molecular docking technique. When compared to the standard drug levodopa, the Vitexin possess better interaction with alpha synuclein by forming 5 hydrogen bonds and highest binding affinity of -6.9 kcal/mol and exhibits as a potent lead molecule in Parkinson’ s therapy.