Ayush entrepreneurs are the creative entrepreneurs to experiment of transforming innovative idea into successful business operations in the area of Ayush. India is the country with rich resources of Ayurvedic products and medicines, tradition of performing Yoga and Meditation that gives advantages for start-ups. The motive of initiating the present research work was to analyze the degree of impact of ayush entrepreneurs on start-ups. The research study also addressed the impacts of ayush entrepreneurs on employability skills.Start-ups in the area of Ayush can create more employment opportunities for the Indian Youth. Researchers identified the scope of the present study within the geographical location of Karnataka state and the respondents include ayush entrepreneurs, employees of start-ups related to ayush enterprises.Research data were collected from primary and secondary sources by identifying the fair representatives of the ultimate population. The structured questionnaires were distributed among the selected respondents and analyzed the data after collecting, classifying and codifying in the systematic manner. The principal outcomes of the research study conveyed the high degree of impacts of Ayush Entrepreneurs on Start-ups and Employability Skillsthat develop the confident among young entrepreneurs in the area of Ayush Industry. The research outcomes also address the employment opportunities for rural and urban population in Karnataka.