Down syndrome is a genetic disorder caused by the presence of all or part of a third copy of chromosome 21. When mothers of down syndrome children experience stress, they use certain strategies to cope with this stress to regulate their emotions. Aim of the study: To assess coping pattern and needs of mothers of children suffering from down syndrome. Design: A descriptive research design was used. Setting: The study was conducted at AL-Tarbih EL-Fikria school for special need children in Fayoum Governorate. Sample. A Convenience sample compromise 100 of Down syndrome children & their mothers. Tools: First tool: Structured interviewing questionnaire include 3 parts : Socio- demographic characteristics for children &their mothers, family and medical history for mother and their children, and mothers' knowledge regarding down syndrome. Second tool: Mothers' needs for caring of their children suffering from down syndrome. Third tool: Mother coping patterns with their children suffering from down syndrome. Results: Illustrated that, 62% of mothers had unsatisfactory total knowledge regarding down syndrome, 65% of mothers were had very much levels of needs , 36 % of mothers positively coping with their down syndrome children Conclusion: There was highly statistically significant positive correlation between total knowledge score and total coping pattern. Recommendation: Provide educational program to parents of children with down syndrome regarding their needs and coping pattern.