Heterocyclic scaffolds play a vital role in the structures of numerous drugs and natural products, owing to their wide range of pharmaceutical and biological activities. Copper has the ability to undergo redox processes and hence plays a pivotal role in catalytic activity and versatility in organic synthesis. Nowadays, Copper based nanoparticles have been extensively investigated as a novel class of catalysts for various chemical transformation. This review focuses on the application of copper-based nanoparticles as catalysts in the synthesis of potential heterocyclic moiety that offers several advantages, that includes low catalyst loading, high atom economy, improved yields, easy separation, cost effective, shorter reaction times, recyclability and reusability of the catalyst.