Rate of cell proliferation plays a vital role in determining the outcome of oral squamous cell carcinoma (OSCC). Numerous markers exist to assess the proliferation of cell, among which mitotic and nucleolar organizer region (NOR) indices are the most feasible techniques. Aim: The aim of the study was to correlate the two indices of proliferation with prognosis of OSCC. Experimental setting and design: Twenty proven cases of OSCC were evaluated for mitotic activity (Mitotic activity index and Volume-corrected mitotic index) and NOR’s (number and area) respectively in H&E and silver nitrate stained slides. These parameters were compared with the prognosis (event of recurrence and death) of OSCC.