Bacterial meningitis and meningoencephalitis are increasing in incidence. The aim of this study was to evaluate the clinical outcomes of the empirical use of antibiotics in bacterial meningitis and meningoencephalitis patients.Antibiotic therapy was considered appropiate if the right type (guideline), dose, interval and duration of administered.Estimated the association between concordance empirical antibiotic therapy with clinical outome patients. There are67 patients with bacterial meningitis and meningoencephalitis in the hospital. The suitability of empirical antibiotics was evaluated using the Gyssens algorithm. Relationship between empirical antibiotics and clinical outcome patients are analyzed with Chi Square (P<0,005). The results from this study showed there were 29 women (43.3%) and 38 men (56.7%). Culture tests were found in only 31 (46.3%) patients. The most commonly used antibiotic is Ceftriaxone. Based on clinical outcomes, 51 (76.2%) patients improved, 15 (22.4%) did not improve. Based on statisticsanalyze there was showed P value <0.05 it was 0,028 for meningitis and 0,039 for meningoencephalitis therapy. The data mean of the appropriateness of empirical antibiotic administered affects to clinical outcomes of patients. The research results obtained can be concluded that the antibiotics used are effective in achieving patient clinical outcomes.