Introduction: Oxidative stress contributes to defective antioxidant defences, possibly leading to type 2 diabetes (T2D). This study aimed to elucidate the T2D risks and antioxidant defences by investigating the correlation between malondialdehyde (MDA), superoxide dismutase (SOD) and catalase (CAT) in T2DM patients. Methodology: In this case-control study, 63 newly diagnosed T2DM patients and 63 healthy individuals served as cases and controls, respectively. The socio-demographic information was recorded. In addition, plasma glucose, HbA1c, MDA, SOD, and catalase were calculated and statistically compared. Results: The mean age of the cases was 47.14±8.16, and the controls were 45.12±6.09 years. The majority of the patients in both groups were married and intermediate-qualified. The mean duration of the smoking was significantly higher in Cases (p=0.0050*). Mean serum urea and creatinine were substantially higher in the case group. The study revealed significant differences in plasma glucose and HbA1c levels between cases and controls (p<0.05). Moreover, MDA levels were substantially elevated in the case group (p<0.0001*). In contrast, SOD (p=0.0025*) and catalase (p<0.0001*) levels were significantly lower in the case group.