Introduction: Anemia continues to be a major public health problem worldwide, particularly among females of reproductive age in developing countries. RBC histogram is an integral part of automated analysis which in association with RBC indices, hematocrit and RBC distribution width provides major clues in the diagnosis and management of red cell disorders Methodology: The present study was done as a retrospective comparative study in a total of 100 adult blood samples, in our study all adult patients with hemoglobin level below 11 gm%. were included The histogram were studied in comparison to their respective Peripheral Blood smears The RBC indices were seen in association with Histogram pattern. In this study we have correlated the RBC histogram abnormalities with peripheral blood smear findings.