Vitamin C is necessary for connective tissue formation and preservation. Vitamin C helps to prevent infections by boosting the immune system and reducing the severity of allergic reactions. The significance of vitamin C and its health advantages in relation to human diseases like atherosclerosis, cancer, mental toxicity, diabetes, and dementia is still up for debate. The primary cause of multiple organ failure and acute respiratory distress syndrome is the inflammatory response in people with Coronavirus disease 2019, especially in those with severe and critical illness. Numerous studies have shown that taking a lot of vitamin C reduced the inflammatory responses that are linked to sepsis and acute respiratory distress syndrome. The objectives of this study were to determine the safety and efficacy of high-dose vitamin C in the 2019 Coronavirus disease. In this review, 76 individuals with Covid illness in 2019 were isolated into two gatherings: a high-portion L-ascorbic acid gathering with 46 individuals, and a standard treatment bunch with 30 individuals