Stress has increasingly become a pressing issue in organizations during recent decades. When an individual encounters an opportunity, demand, or resource that aligns with their desires but the outcome remains uncertain and crucial, it puts them in a heightened state. While stress can have some positive effects on workers within an organization, it often exceeds their capacity to cope, leading to negative consequences. Aims and objective: To find out the correlation between work related musculoskeletal pain disorder and job stress and vulnerable population and create awareness among bank employees in New Delhi. Materials and Methods: The present observational study was conducted on 60 bank employees in Narela, New Delhi, India, over a period of 3 months from January 2023 to March 2023 to evaluate first Orebro musculoskeletal pain (OMP) and Perceived stress scale (PSS). The range, mean and standard deviation of each parameters were measured by using Statistical Package for the Social Sciences (SPSS) latest version (version 21.0) and Student’s t-test was applied for bilateral comparison. Observation and results: Among the 60 samples of bank employees the range of OMP pain score were 28 - 119 and average score were 76 ± 24.2. And the PSS pain score ranges from 7 - 28, with an average value of 17.2 ± 4.06. Significance difference was observed between OMP pain score and PSS pain score level of significance is p≤0.05. Conclusion: This observational study explores the correlation between work-related pain disorders and occupational stress among employees working in both public and private banks. The study findings indicate a notable & meaningful connection between work-related musculoskeletal pain issues and job stress, drawing upon comprehensive data collection and evaluation