Research and oral medicine are inseparable entities with profound impact on the practice of dentistry.The COVID-19 pandemic had posed a variety of challenges to research in this field. As researchers strived to overcome these challenges, it turned out that it was still possible to conduct research effectively throughout the pandemic period with a few modifications to research methodology and procedures. This paper focuses on the COVID-19 pandemic and its influence on the scope and strategies of research in oral medicine and radiology.