Background: The novel coronavirus 2019 or COVID-19 pandemic has brought about a global public health crisis, providing care was emotionally difficult for healthcare workers. Uncertainty, stigmatization, and potentially exposing their families to infection were prominent themes for health care workers during epidemic Aim of the study: was to investigate relationship among COVID-19-social stigma and nurses' preparedness. Research design A descriptive correlational design was used to conduct this study. Setting: This study was conducted at Al-Ahrar Zagazig Teaching Hospital. Subjects: Simple random sample was selected from nurses (n= 230). Tools of data collection: COVID-19 Social stigma scale and Nurse's preparedness scale Results: Studied nurses had a high level of COVID-19 social stigma and Nurse's preparedness during COVID-19 outbreak. Conclusion there was statistically significant negative association between COVID-19 social stigma and Nurse's preparedness. Recommendations: Therefore, strategies and measures should be taken, to reduce COVID-19 social stigma such as : enforce positive public attitudes toward nurses; continuing education and training sessions; and support HCWS in healthcare facilities should provide with occupational safety standards, equipment, consumables, training and Personal protective equipment