This review has detailed the dangerous pandemic through which millions of people across the globe suffered, i.e., COVID-19. Studies showed that it was affecting humans by using ACE-2 receptors. Researchers proved that the ACE-2 receptor shows its expression in keratinocytes and sweet glands. Hence, it is clear that the skin is a potential target for the infection. Hence, we conducted this review to learn about different clinical aspects and presentations due to this infection. We conclude that all clinicians showed basic knowledge about its etiopathology, clinical features, and severity for treatment aspects.