COVID-19 is a respiration-related ailment brought on through SARS-CoV-2 and was once recognized in China’s Wuhan city. More than 223 nations are affected by the ailment worldwide. The new variants of the COVID-19 virus are inflicting problems, from average to life-threatening pneumonia and acute respiratory distress syndrome (ARDS). Presently, there are a hundred and seventy vaccine candidates, out of which 10 have been permitted by the WHO for vaccination, such as Ad26.COV2. S, Pfizer/BioNTech, COVISHIELD, Covovax, Moderna, Co-vivac, and some different vaccines to fight the deadly SARS-CoV-2 infection. From all these vaccines, Pfizer/BioNTech and Moderna are showing the best efficacy towards COVID-19. These vaccines are pretty environment friendly towards COVID-19 disease, however their potentiality in opposition to new variations stays a question. COVID-19 vaccines are relatively fine at preventing severe illnesses, hospitalizations, and death. The antibodies elicited by way of beforehand contamination or vaccination are the key for viable safety in opposition to SARS-CoV-2 The trouble has been exacerbated by new statistics from Africa on the origins of the novel contagious SARS-CoV-2 strains .These new lines occurs due to unique mutations in spike protein , which adjust SARS-CoV-2 transmission and infection capabilities , limiting the efficacy of the covid -19 vaccination Hence, there is a need to find a plausible vaccine against it.