Dengue virus infection is a global health threat, necessitating the development of a safe and effective vaccine. Immunoinformatics, an emerging field at the intersection of immunology and bioinformatics, offers innovative approaches for accelerated dengue vaccine development. This review explores the potential of immunoinformatics in decoding the complexities of dengue virus and leveraging this knowledge for revolutionary vaccine design. By integrating genomic and proteomic information, immunoinformatics aids in identifying viral antigens and epitopes capable of inducing robust immune responses. Computational algorithms predict the immunogenicity and conservation of these targets across dengue serotypes, providing valuable insights for vaccine design