Goal: This study aimed to create mental toughness in patients with Multiple Sclerosis using therapeutic interventions based on stigma experiences and positive psychotherapy in a randomized clinical trial. Method: This study fell under pre-and post-test with a one-month follow-up design involving a control group. All Multiple Sclerosis patients presenting to a neurologist clinic and the patients who had been informed via online notifications on social networks comprised the statistical population. Out of these patients, 45 people were selected via the convenience method and randomly placed in two experimental (positive psychotherapy and experiences based on lived experiences of social stigma) and control groups of 15 people each. After randomization, all subjects filled in the Mental Toughness Questionnaire before and after the therapy in a one-month follow-up. Because the covariance analysis assumptions were not met, repeated measurement ANOVA and SPSS software (version 21) were used to analyze the data. Findings: Covariance analysis results indicated that both positive psychotherapy (F=309.68 and Sig.=0.001) and lived experiences (F=657.01 and Sig. 0.001) had significant effects on mental toughness. Conclusion: The findings revealed that positive psychotherapy and lived experiences helped increase the mental toughness of subjects