Nyctanthes arbor-tristis is an Ayurvedic herb that has been used for centuries in India for its medicinal properties. The herb has anti-inflammatory, analgesic, and antipyretic qualities, this plant is well-known in traditional Indian medicine, specifically in Ayurveda, for its diverse pharmacological properties. It is utilized for its antispasmodic, anti-arthritic, anti-inflammatory, antidiabetic, immune-stimulant, antibacterial, antileishmanial, antipyretic, antidiabetic, antiviral, antimicrobial, antioxidant, anthelminthic, anti-allergic, hepatoprotective, and CNS depressant actions. Nano-emulsiongel: The nanoemulgel's improved dermis-layer adhesion properties and increased solubility provide a raised concentration gradient in the epidermis, which affects the amount of medicine that diffuses into the epidermis as it descends the gradient. This nanoemulgel has been the attention of several researchers who are working to develop a variety of drugs that can be utilised to treat different dermis problems. Result: At 1, 2, 3, 4, and 5 hours after receiving a carrageenan injection, the group treated with the high dose of Polyherbal Nanoemulgel showed a significantly lower level of paw edoema than the reference control group (p0.05). Although the paw edoema was reduced in the low and mid-dose groups as well, the difference from the reference control group was not statistically significant. Conclusion: The findings of this study show that, in comparison to the normal control group, the polyherbal nanoemulgel dramatically decreased the paw edoema volume in a dose-dependent way. The greatest anti-inflammatory efficacy was seen at the high dose of the nanoemulgel (500mg).