The supreme life essence of all body tissues, known in Ayurveda as Ojas, is in charge of defending the human body against illness and infirmity. The state of resistance to infectious disease is referred to as immunity. In Ayurveda, the term Vyadhikshamatva is used to give a very concise explanation of immunity. Several Acharyas and their commentators had outlined different elements—like Bala, Ojas, Agni, etc.—which contribute to the development of the Vadhikshamatva in ayurvedic texts. An attempt is made to present Ayurveda theories on immunity and vaccination in this review paper. According to Ayurveda, Ojas, the higher life essence of all bodily tissues, is in charge of protecting the body against illness and infirmity. The ability to fend off infectious disease is referred to as immunity. The term Vyadhikshamatva is used in Ayurveda to give a very simple explanation of immunity. The Vadhikshamatva is developed by a number of variables, including Bala, Ojas, Agni, and others, which were detailed by several Acharyas and their commentators in ayurvedic texts. The goal of this review paper is to present Ayurveda theories on immunity and immunization