Currently, with the expansion of various industries, there is a demand for many cutting tools. Carbide-cutting tools are widely used in many industrial sectors due to their high strength and wear resistance. However, machining S45C steel without coolant tends to cause rapid tool wear. As a result, coated carbide cutting tools are preferred because of the fact that coating can increase tool life. However, the coated carbide tool is fairly costly, which raises the overall cost of the product. Thus, reducing tool wear has become an important issue. The application of cryogenic methods is an alternative way to decrease tool wear and expand tool life. This research studied the tool wear of uncoated carbide-cutting tools performed on the S45C steel shafts under different conditions including no special treatment inserts with no cooling while turning, cryogenically treated inserts with no cooling while turning, and cryogenically treated inserts with cryogenic cooling while turning. The result of this experiment indicated that the cryogenic treatment can reduce tool wear of uncoated carbide inserts when compared with non-treatment. Furthermore, the use of cryogenic treatment together with cryogenic cooling demonstrates outstanding performance in increasing tool life because the tool wear was down to more than half when turning at the cutting speed and feed rate of 200 mm/min and 0.26 mm/rev, respectively.