Application of deep eutectic solvents, DES in diverse fields of science, organic synthesis, electrochemistry, biotechnology, and food, cosmetic, chemical, and pharmaceutical industries is drastically increasing day by day due to the special properties like lower melting point, less volatility, biodegradability, less toxicity, and other advantages compared to organic solvents. DES aids in the improvement of the physico-chemical properties of the solvent in an economically feasible way. API is the main constituent of therapeutic drugs and pharmaceutical compounds. Most pharmaceutical and chemical industries employ the process of crystallization as the final step for the separation and purification of API, and to obtain the drugs in a desired pure state in a cost-effective method. India is the second largest manufacturer of API, next to china. The cost of production depends on the raw materials used for solvent, the method of solvent preparation, the recovery of the final product, etc. The stability and safety of pharmaceutical products are analyzed for quality control checks to adhere to environmental and health safety regulations. Judicial selection of solvent and method of crystallization is critical as it affects the size, structure and polymorphism of final product obtained. Conventional organic solvents form a large proportion of solvents used for the crystallization of pharmaceutical drugs. The toxicity, low bioavailability, poor dissolution rates, and high costs lead to an intense search for alternative green solvents